Hu IL-21 PE 3A3-N2.1 100Tst

产品编号：BD-560463 品牌：BD-Pharmingen 原厂货号：560463
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

100Tst

运保温度:

Store undiluted at 4°C

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描述：

Human Interleukin-21 (IL-21) is a member of the type I cytokine family that is encoded by a gene resident on chromosome 4. The mature form
of human IL-21 is a 131 amino acid protein. IL-21 is produced by activated NKT and multiple CD4+ T cell subsets including effector memory
and central memory CD4+ T cells and differentiated T helper cell subsets polarized towards Th17 cell and T follicular helper (Tfh)
phenotypes. IL-21 plays important protective roles in the regulation of hematopoiesis and both innate and adaptive immune responses and
adverse roles in promoting autoimmunity. IL-21 costimulates the proliferation and differentiation of CD4+ T cells. It enhances the proliferation
of and cytotoxicity mediated by natural killer (NK) cells and CD8+ T cells. IL-21 costimulates B cell proliferation and differentiation into
plasma cells producing immunoglobulins with IgG isotypes. IL-21 can also regulate the functions of dendritic cells and other myeloid cells.
IL-21 exerts its biological activities by binding to and activating the Janus activating kinases (JAK1 and JAK3) and signal transducers and
activators of transcription (STAT1, STAT3, STA5a and STAT5b) signaling pathways through the IL-21 receptor (IL-21R) complex. The
IL-21R complex is comprised of the IL-21R alpha subunit and the common cytokine receptor gamma subunit (γ c; CD132).
The monoclonal 3A3-N2 antibody specifically binds to human IL-21.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 X 10e6 cells in a 100-μl experimental sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
5.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.