Hu IL-17A PE SCPL1362 100Tst

• 产品编号：BD-560436      品牌：BD-Pharmingen       原厂货号：560436
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

人IL-17A，也被称为IL-17，是一种促炎症细胞因子，由6号染色体的IL17A基因编码。IL-17A由两个136aa的多肽通过二硫键连接组成同型二聚体。它是结构相关细胞因子的IL-17家族一员。活化的记忆T细胞，特别是Th17细胞（与Th1和Th2细胞不同的可产生IL-17A的CD4+ T细胞）可产生IL-17，并提供针对病原体的保护性免疫。活化的CD8+ T细胞、γδT细胞、NK细胞和嗜中性粒细胞，均可被活化，产生IL-17A。IL-17A结合并通过IL-17受体（IL-17R）发挥其生物学活性，该受体由包括成纤维细胞、上皮细胞和内皮细胞、单核细胞/巨噬细胞和肥大细胞在内的多种靶细胞表达。IL-17R的广泛表达，可以解释多种组织的针对IL-17发生的反应。IL-17可诱导间质细胞分泌细胞因子和趋化因子，这些因子参与炎症反应和造血过程。例如，IL-17诱导的成纤维细胞产生IL-6、IL-8、G-CSF和ICAM-1。SCPL1362抗体可与人IL-17A发生反应。

原厂资料：

Human IL-17A, also known as IL-17, is a proinflammatory cytokine that is encoded by the IL17A gene in chromosome 6. IL-17A is produced as a disulfide-linked homodimer comprised of two mature 136-amino acid polypeptides. It is a member of the IL-17 family of structurally related cytokines, designated IL-17A through IL-17F. Activated memory T cells, especially Th17 cells (specialized IL-17A-producing CD4+ T cells distinct from Th1 and Th2 cells) produce IL-17 and provide protective immunity against pathogens. Activated CD8+ T cells, γδT cells, NK cells and neutrophils can also be activated to produce IL-17A. IL-17A binds to and exerts its biological activity through IL-17 receptors (IL-17R) that are expressed by a variety of target cells including fibroblasts, epithelial and endothelial cells, monocytes/macrophages and mast cells. The ubiquitous IL-17R expression pattern may explain the broad tissue responsiveness to IL-17. IL-17 induces stromal cells to secrete cytokines and chemokines involved in inflammatory and hematopoietic processes. For example, IL-17 induces fibroblasts to produce IL-6, IL-8, G-CSF and express increased surface ICAM-1. The SCPL1362 antibody reacts with human IL-17A.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental sample (a test).
2.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
3.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
4.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.