Hu IL-21 Receptor PE 17A12 100Tst

• 产品编号：BD-560264      品牌：BD-Pharmingen       原厂货号：560264
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

IL-21 receptor (IL-21R) encodes a 538 amino acid cytokine receptor with an extracellular domain consisting of one copy of the conserved
WSXWS -containing cytokine-binding domain. The IL-21 receptor combines with the common cytokine-receptor γ-chain to form a functional
receptor for IL-21. IL-21 is mainly produced by CD4+ T cells. IL-21R is preferentially expressed by B cells, T cells, NK cells, some
populations of myeloid cells, keratinocytes, and dendritic cells. Binding of its ligand, IL-21, in these cells results in the activation of the
Jak/Stat signal transduction pathway. The effects IL-21 ligand binding has pleiotropic actions such as augmenting the proliferation of T cells,
driving of B cells into memory cells, terminally differentiating plasma cells and augmenting the activity of natural killer cells. IL-21 receptor has
anti-tumor activity and might have a role in the development of autoimmunity; it has been reported that the IL-21 receptor affects the
homeostasis of regulatory T cells and it could enhance T cell-activated responses in human immune-inflammatory diseases.

原厂资料：

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 X 10e6 cells in a 100-μl experimental sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
5.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.