PLC-Gma2 Alexa 488 K86-1161 50Tst

• 产品编号：BD-560135      品牌：BD-Pharmingen       原厂货号：560135
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositol biphosphate to inositol triphosphate and diacylglycerol. The former
causes release of calcium from the endoplasmic reticulum, while the latter is an activator of Protein Kinase C. Within the PLC family, PLC-g
is the only member that contains SH2 and SH3 domains. These domains enable it to interact with receptor tyrosine kinases and become
enzymatically activated via phosphorylation. It exists as two isoforms: 1) PLC-g1, which is ubiquitously expressed, and 2) PLCg2, found
primarily in the lymphoid system. PLC-g is essential for growth factor-induced cell motility and mitogenesis. Overexpression of PLC-g is
evident in several forms of cancer, and it has been identified as a key mediator of PDGF-dependent cellular transformation. Thus regulation of
PLC-g activity by growth factors is involved in cell growth and transformation.
Although the immunogen for generation of the K86-1161 monoclonal antibody was a phosphorylated peptide, peptide blocking studies
demonstrated that the mAb recognizes PLC-g2 regardless of phosphorylation status. This antibody was raised to a unique region of PLC-γ2
and is predicted not to crossreact with PLC-γ1

原厂资料：

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.