Src (pY418) Alexa 488 K98-37 50Tst

• 产品编号：BD-560095      品牌：BD-Pharmingen       原厂货号：560095
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

The non-receptor protein tyrosine kinases of the Src family have similar domain structures with considerable sequence homologies. They are
associated with cell membranes and are activated by a wide variety of cell-surface receptors. Through their participation in cell-signaling
cascades that mediate an array of cellular responses, they control essential cellular activities.
Src, the prototype of the Src family, is encoded by the SRC protooncogene, which is a homolog of the v-Src gene of the Rous sarcoma virus.
Src’s oncogenic potential may be a consequence of its role as a regulator of cell growth, morphology, motility, and adhesion. The protein
contains domains that mediate protein-protein interactions and regulation of its tyrosine kinase activity. Mechanisms that regulate Src activity
include phosphorylations of serines and tyrosines in most of the domains and interactions with receptor proteins, integrins, and other binding
proteins. In particular, autophosphorylation at tyrosine 418 (Y418) activates tyrosine kinase activity. Phosphorylations at other sites are
mediated by kinases such as cdc2, CSK, and CHK in signaling cascades and may up- or down-regulate Src activity.
The K98-37 monoclonal antibody recognizes the phosphorylated Y418 in the protein kinase domain of activated Src. The orthologous
phosphorylation sites in chicken, mouse, and rat Src are Y415, Y423, and Y418, respectively. Because of sequence similarities in this region,
it may also recognize the homologous sites of some other Src family members: Lyn (pY396), Fyn (pY420), Hck (pY410), Lck (pY394), and
Yes (pY425).

原厂资料：

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.