ATM (pS1981) Pure K88-534 100ug

• 产品编号：BD-560007      品牌：BD-Pharmingen       原厂货号：560007
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

ATM is the gene that is mutated in ataxia telangiectasia, an autosomal recessive hereditary disease that is characterized by delayed motor and sexual
development, weakened immunity, multiple skin changes, increased sensitivity to ionizing radiation, and increased risk of developing certain cancers.
The protein encoded by ATM is a phophoinositide-3-kinase-related protein kinase that is found in the nucleus and is responsible for early responses to
the changes in chromatin structure caused by DNA double-strand breaks. Inactive wild type ATM protein forms homodimers or higher order
multimers in which the C-terminal kinase domains are inhibited. It has been proposed that multimeric ATM is recruited to DNA double-strand breaks
through interactions between its N-terminal HEAT domains and specific chromatin protein complexes. The inhibition of the kinase domains is lifted,
resulting in auto-phosphorylation of the ATM at a single serine site and disruption of the multimers. The phosphorylated state of ATM is a rapid and
highly sensitive indicator that cells have been exposed to agents that cause DNA double-strand breaks. The kinase domains of the resulting ATM
monomers are accessible to a wide variety of substrates that are involved in DNA repair, cell-cycle regulation, and apoptosis. Thus ATM is a central
regulator of cellular responses to ionizing radiation, and cells that lack ATM undergo radioresistant DNA synthesis and are resistant to γ
radiation-induced apoptosis.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at 4°C .