Rat CD62L Biotin HRL1 100ug

• 产品编号：BD-559989      品牌：BD-Pharmingen       原厂货号：559989
• 产品分类：抗体 > 一抗 > 表位标签和报告基因特异性抗体
• 应用分类：

描述：

The HRL1 antibody reacts with L-selectin (LECAM-1, CD62L), which is detected on a small percentage of thymocytes and on most
neutrophils and peripheral lymphocytes. CD62L is a 62-kDa (on neutrophils) or 65-kDa (on lymphocytes) receptor, with lectin-like and
epidermal growth factor-like domains, which binds to sialylated oligosaccharide determinants on high endothelial venules (HEV) in peripheral
lymph nodes. This member of the selectin adhesion molecule family appears to be required for lymphocyte homing to peripheral lymph nodes
and to contribute to neutrophil emigration at inflammatory sites. L-selectin is rapidly shed from lymphocytes and neutrophils upon cell
activation. In the mouse, the level of CD62L expression distinguishes naive CD4+T cells from effector/memory T helper cells. HRL1 antibody
inhibits the ligand-binding activity of Lselectin in in vitro assays and slows in vivo leukocyte rolling on microvascular endothelium.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.