Ms CD120b Pure TR75-89 500ug

• 产品编号：BD-559916      品牌：BD-Pharmingen       原厂货号：559916
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

The TR75-89 antibody reacts with the extracellular region of CD120b, the 75 kDa receptor for the mouse cytokines, tumor necrosis factor
(TNF, aka TNF-α) and lymphotoxin-alpha (LT-α, aka lymphotoxin, TNF-β). This receptor, referred to as the p75 or Type II Tumor Necrosis
Factor Receptor (TNFRII), or TNFRSF1B, is expressed by a variety of cell lines and normal cell types including T cells, monocytes,
macrophages, and neutrophils. Resting B cells express low or undetectable levels of TNFRII whereas mature erythrocytes are uniformly
negative for TNFRII expression. In addition, the TR75-89 antibody can bind to a soluble, truncated form of the mouse Type II TNFR that is
shed by cells in response to certain stimuli, e.g., cells treated with LPS or TNF. The in vivo administration of nonblocking, nonagonistic
TR75-89 antibody reportedly results in the linear accumulation of shed, soluble forms of p75 TNFR in the circulation. The TR75-89 antibody
does not recognize the 55 kDa (p55) Type I TNFR (aka, CD120a). TR75-89 does not block the binding and does not neutralize the bioactivity
of the TNF ligand on L929 target cell populations that express p75 (and p55) TNFR. The immunogen used to generate the TR75-89
hybridoma was a purified, soluble extracellular domain of the mouse Type II TNFR.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.