Ms/Hu IKK Gma Pure C73-764 100ug

• 产品编号：BD-559675      品牌：BD-Pharmingen       原厂货号：559675
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

The transcription factor NF-κB, (nuclear factor kappa-B) is controlled by interaction with an inhibitory subunit, IκB, which restricts NF-κB to
the cytoplasm. Following stimulation by various cytokines or other stimuli, IκB becomes degraded and NF-κB is released to the nucleus. The
release of IκB from NF-κB is a critical step in the activation of NF-κB signal pathways. A group of proteins form an NF-κB regulatory
complex, or signalsome. Two members of this complex are a pair of closely related serine/threonine kinases, IKKα and IKKβ (aka IKK-1 and
IKK-2), which phosphorylate critical residues of IκB, thus targeting it for subsequent degradation. The IKK complex contains similar amounts
of IKKα, IKKβ, as well as two other polypeptides, which are differentially processed forms of a third subunit, IKKγ. IKKα and IKKβ become
activated following phosphorylation by upstream kinases, including NF-κB-inducing kinase (NIK) and MEKK1. IKKγ interacts preferentially
with IKKβ and is required for the activation of the IKK complex. Thus the IKK kinases play an important role in the activation of NF-κB.
IKKγ migrates as a doublet between 50-55 kDa in SDS-PAGE.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.