Pig CD4a FITC 74-12-4 100ug

产品编号：BD-559585 品牌：BD-Pharmingen 原厂货号：559585
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

100ug

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The 74-12-4 (also known as clone PT4) antibody reacts with CD4, a 55-kDa antigen expressed on T lymphocytes. This antibody does not
react with CTL effectors, CTL precursors, or NK cells (ie, CD8[bright] cells) and it does not cross-react with human or bovine cells. Two
peripheral T-helper lymphocyte phenotypes can be distinguished in the pig: CD4+CD8- and CD4+CD8[dull]. mAb 74-12-4 has been reported
to inhibit proliferative responses of PBL to mitogen, soluble antigen, and lloantigen. It is only marginally effective for in vivo depletion of
peripheral CD4+ T cells. Two alloantigenic forms of CD4 have been recognized in miniature swine based upon their recognition (CD4.1) or
lack of recognition (CD4.2) by mAb 74-12-4; the CD4.2 phenotype displays an autosomal recessive, non-MHC-linked, pattern of inheritance.
The molecular basis for the polymorphism is a cluster of nucleotide differences leading to multiple amino-acid substitutions in the Ig
CDR2-like loop structure. This mAb was clustered as anti- CD4a at the First International Swine CD Workshop. It has been reported to
cross-react with chicken leukocytes.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
4.The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.
5.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.