The MR106 antibody reacts with CD106, the ~110 kDa transmembrane vascular cell adhesion molecule-1 (VCAM-1). Expression of CD106
on endothelial cells is induced by inflammatory cytokines and in certain pathologic conditions. In the rat bone marrow, CD106 has been
reported to be expressed on dendritic cells and subsets of the myeloid lineage, but not detectable on peripheral leukocytes. CD106 has been
reported to be a counter-receptor for VLA-4 (α4β1 integrin) and α4β7 integrin, and it plays an important role in leukocyte extravasation,
particularly at sites of inflammation.
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注意事项:
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.