Reacts with homing-associated cell adhesion molecule (HCAM), CD44, an integral membrane glycoprotein that exists in a variety of isoforms
(CD44 variants). CD44 is synthesized as a 37 kDa polypeptide that is converted to a 80-90 kDa form by glycosylation via N- and O-linkages,
or to a 180-200 kDa form by the addition of chondroitin sulfate. It is expressed on leukocytes, erythrocytes, epithelial cells and weakly on
platelets. Depending on the cell type, CD44 may participate in a variety of functions including cell adhesion, motility and cell activation.
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注意事项:
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.