CDK2 Rbt Ser Poly13131 0.1mL

产品编号：BD-558896 品牌：BD-Pharmingen 原厂货号：558896
产品分类：抗体 > 一抗 > 蛋白特异性一抗
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包装：

运保温度:

Store undiluted at 4°C .

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描述：

Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell cycle control in eukaryotes. Cdks
are catalytic subunits whose activity requires interaction with their regulatory subunits, the cyclins, as well as specific phosphorylation events.
The precise timing of cyclin-cdk activity during the cell cycle determines whether the cell cycle continues or becomes blocked. Cdks 2, 4, 5,
and 6 may associate with D-type cyclins. Interaction between cdk2 and cyclin E during G1/S transition creates a complex with histone H1
kinase activity. This complex is thought to be required for the initiation and progression of DNA replication during S phase. Cdk2-cyclin A
complexes appear during late S phase and also play a role in progression of DNA replication. Substrates for cdk-cyclin complexes include
nuclear lamins, histones, oncogenes, (c-src, c-abl, SV40 large-T), tumor suppressor genes (e.g., RB and p53), nucleolin, RNA polymerase II
and others. Cdk2 migrates at ~33 kDa on SDS-PAGE. The polyclonal antibodies recognize human and mouse cdk2. The antibodies do not
react with other known cdk proteins. A synthetic peptide corresponding to amino acids 287-298 (QDVTKPVPHLRL) at the C-terminus of
human cdk2, with the addition of a C-terminal cysteine residue (C) to facilitate coupling to KLH, was used as immunogen.
The polyclonal antibodies recognize human and mouse cdk2. The antibodies do not react with other known cdk proteins. A synthetic peptide
corresponding to amino acids 287-298 (QDVTKPVPHLRL) at the C-terminus of human cdk2, with the addition of a C-terminal cysteine
residue (C) to facilitate coupling to KLH, was used as immunogen.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at 4°C .