Hu TRAF2 Pure C90-481 100ug

• 产品编号：BD-558890      品牌：BD-Pharmingen       原厂货号：558890
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

TRAFs (TNF receptor associated factors) are signal transducing molecules which participate in forming TNF/Nerve Growth Factor
receptor-associated signalling complexes. TRAF proteins share a novel C-terminal homology region, the “TRAF” domain, a coiled-coiled
region and the majority have Zinc/RING finger motifs. At least six TRAF proteins (TRAFs 1-6) have been identified. These proteins are
cytoplasmic adapters; they bind to cytoplasmic domains of various receptors and can function to recruit other proteins to a signaling complex
thereby promoting intracellular signal transduction. Specifically, TRAF2 has been shown to interact with the following surface receptors:
TNFRII, CD27, CD30, CD40, 4-1BB, Ox40, HVEM/ATAR and LMP-1. TRAF2 has also been shown to associate with intracellular proteins,
including TRADD, FADD, I-TRAF/TANK, TRIP, A20, c-IAP1 and 2, Casper, RIP and NIK. Thus, the interaction of TRAF2 with these
various receptors and intracellular proteins plays an important role modulating downstream events which can result in inducing cell death or
keeping cells alive. For example, cells deficient in TRAF2 demonstrated increased sensitivity to TNF-induced cell death, but a decrease in
TNF-induced JNK activation, and little change on NF-kB activation. TRAF2 is detected at ~ 53 kDa in western blot analysis. The C90-481
antibody reacts with human TRAF2. A synthetic protein freagment corresponding to amino acids 93-199 of human TRAF2 was used as
immunogen.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at 4°C .