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Ms CD49b PE HM Alp2 100ug

  • 产品编号:BD-558759      品牌:BD-Pharmingen       原厂货号:558759
  • 产品分类:抗体 > 一抗 > 染料标记抗体
  • 应用分类:
 
包装: 100ug
运保温度: Store undiluted at 4°C
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描述:

The HMα2 antibody reacts with integrin α2 chain (CD49b), the 150-kDa transmembrane glycoprotein that non-covalently associates with the integrin β1 subunit (CD29) to form the integrin α2β1 complex known as VLA-2. VLA-2, a receptor for collagen and laminin, is expressed on some splenic CD4+ T lymphocytes and NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, splenic NK cells, epithelial cells, and platelets; but it is not on thymocytes or Peyer’s-patch or lymphnode lymphocytes. The expression of VLA-2 is upregulated on lymphocytes in response to mitogens. The HMα2 antibody has been reported to partially block the interaction of T-cell blasts, but not NK cells, with collagen. Purified HMα2 mAb blocks the staining of splenic NK cells by the anti-CD49b/Pan-NK Cells mAb DX5 (Cat. No. 553858, for the PE conjugate). Therefore, mAb HMα2 may be used like the DX5 mAb for identification of NK cells.


注意事项:

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results. 2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. 3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. 4.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. 5.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.


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