Bta Catenin (pS45) PE K63-363 50Tst

产品编号：BD-558638 品牌：BD-Pharmingen 原厂货号：558638
产品分类：抗体 > 一抗 > 染料标记抗体
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运保温度:

Store undiluted at 4°C

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描述：

b-catenin is a 92-kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula adherens). Deletions in the cytoplasmic domain of E-Cadherin that eliminate b-catenin binding also result in a loss of cell adhesion, indicating that this binding is essential for E-Cadherin function. b-catenin is also a signaling molecule in the Wnt pathway that controls many aspects of cellular development by regulating gene transcription in association with the T cell factor/lymphocyte enhancer factor (TCF/LEF) transcriptional activator complex. Phosphorylation of b-catenin by glycogen synthase kinase-3 (GSK-3) controls the intracellular levels of b-catenin by inhibiting its ubiquitination and degradation. The resulting accumulation of b-catenin is associated with and may cause a variety of cancers. Multiple regulatory mechanisms control cellular homeostasis by regulating the levels of b-catenin.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 X 10e6 cells in a 100-μl experimental sample (a test). 2.Since applications vary, each investigator should titrate the reagent to obtain optimal results. 3.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. 4.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. 5.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.