p120Catenin(pS268) A647 9a.390 50Tst

产品编号：BD-558559 品牌：BD-Pharmingen 原厂货号：558559
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

50Tst

运保温度:

Store undiluted at 4°C

到货周期：

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描述：

The membrane associated protein pp120 Src substrate (p120 catenin, p120cas) was identified as a tyrosine kinase substrate that is
phosphorylated in Src-transformed cells. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate b-catenin and
g-catenin proteins in its 42-amino acid Arm domain. p120 catenin is localized to the E-Cadherin/catenin cell adhesion complex. Like b- and
g-catenin, p120 catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain. It exists as four isoforms that
range in size from 90 to 115 kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered expression
contributes to malignancy. Phosphorylation of multiple serine (S252, S268, S288, and S873), and threonine (T310 and T910) residues in
p120 catenin may regulate its activity. The S873 residue is phosphorylated after PKC activation, while the S268 site is dephosphorylated after
PKC activation. The latter residue is phosphorylated in vitro by p160 Rock. S252 and T310 residues are phosphorylated in vitro by GSK3b.
Thus, p120 catenin function may be regulated in a complex manner through both serine and threonine phosphorylation.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.