FAK (pS910) PE K73-480 50Tst

• 产品编号：BD-558540      品牌：BD-Pharmingen       原厂货号：558540
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

原厂资料：

Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that associates with integrins in focal adhesions. Its cellular localization is directed by a 125-amino acid sequence at the C terminus called the "Focal Adhesion Targeting" (FAT) domain, and the phosphorylation state of serine 910 (S910) in the FAT domain may regulate the assembly of focal adhesions. Furthermore, the binding of extracellular matrix ligands to integrins triggers tyrosine phosphorylations near FAK’s kinase domain that increase its kinase activity, and additional tyrosine phosphorylations near proline-rich motifs create binding sites for the SH2 domains of various adaptor proteins. FAK's ability to bind numerous structural and signaling proteins via a variety of interactions regulates FAK’s targeting to focal adhesions, modulates its kinase activity, and initiates intracellular signaling cascades. Thus, studies suggest that FAK may integrate cellular events controlling cell motility, growth, and invasiveness.

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 X 10e6 cells in a 100-μl experimental sample (a test). 2.Since applications vary, each investigator should titrate the reagent to obtain optimal results. 3.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. 4.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. 5.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.