CREB(S133)ATF-1(S63) A488 J151-21 50Tst

• 产品编号：BD-558435      品牌：BD-Pharmingen       原厂货号：558435
• 产品分类：抗体 > 一抗 > 染料标记抗体
• 应用分类：

描述：

Transcription of various genes is regulated by the cyclic AMP (cAMP) signal transduction pathway through a family of cAMP Responsive
Element (CRE)-Binding transcription factors that include CREB, CREM (CRE Modulator), and ATF-1 (Activating Transcription Factor 1).
The genes for these transcription factors encode multiple isoforms that are created by alternative splicing, alternative initiation codons, and
alternative intronic promoters. Homo- and heterodimers of these members of the basic domain-and-leucine zipper superfamily of proteins
bind the palindromic TGACGTCA sequence of CRE. CREB is expressed in all somatic cells, and many different stimuli activate CREB by
phosphorylation of its serine 133 (S133). The transcriptional activity and specificity of CREB are regulated by the signaling pathways
initiated by the various stimuli. Transcriptional regulation by CREB family members has been implicated in many physiological responses to
extracellular and environmental stimuli, such as memory, tissue growth and development, and homeostasis.
The J151-21 monoclonal antibody recognizes the phosphorylated S133 of human CREB in addition to cross-reacting with S63 of human
ATF-1.

原厂资料：

注意事项：

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.