CD117 (pY568/pY570) Pure K39-686 100ug

• 产品编号：BD-558390      品牌：BD-Pharmingen       原厂货号：558390
• 产品分类：抗体 > 一抗 > 磷酸化抗体
• 应用分类：

描述：

CD117 (also known as c-kit) is a transmembrane tyrosine kinase receptor that binds stem cell factor (SCF, also known as kit ligand, mast cell
growth factor, and steel factor) and is involved in the regulation of a wide range of tissues at various developmental stages. CD117 has been
reported to play major roles in the regulation of hematopoiesis and germ cell proliferation and survival. Mutations of c-kit are associated with
a wide variety of cancers and developmental diseases. Upon activation by its ligand, CD117 (c-kit) has been reported to dimerize and
autophosphorylate at multiple cytoplasmic sites, which bind to downstream signal transduction molecules. Specifically, the phosphorylated
tyrosines 568 and 570 (pY568/pY570) in the juxtamembrane domain of c-kit bind to several signaling molecules, including the adapter
proteins SHC and APS; the tyrosine kinases Lyn, Fyn, and CHK; and the protein tyrosine phosphatase SHP-2, all of which may interact to
regulate SCF signaling. The K39-686 clone has been reported to recognize the phosphorylated pY568/pY570 of human c-kit. The
orthologous phosphorylation sites in mouse c-kit are pY567 and pY569.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at 4°C .