BLNK (pY84) Pure J117-1278 100ug

产品编号：BD-558366 品牌：BD-Pharmingen 原厂货号：558366
产品分类：抗体 > 一抗 > 磷酸化抗体
应用分类：

包装：

100ug

运保温度:

Store undiluted at 4°C .

到货周期：

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描述：

B cell activation is initiated by crosslinking the B cell receptor, which leads to activation of non-receptor protein tyrosine kinases (PTK),
including Btk, Syk, and three Src kinases, Fyn, Lyn, and Blk. Activated PTKs then phosphorylate multiple cellular proteins involved in B
lymphocyte signaling. Syk is responsible for the tyrosine phosphorylation of B cell linker protein (BLNK), a member of the SLP-76 family of
adapter proteins. Phosphorylation of human BLNK at tyrosines 84, 178, and 189 (Y84, Y178, and Y189) creates docking sites for PLCg2,
leading to the activation of downstream signaling pathways.
The J117-1278 monoclonal antibody recognizes the phosphorylated Y84 of BLNK.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at 4°C .