Stat2 (pY690) Pure 7a/Stat2 100ug

• 产品编号：BD-558095      品牌：BD-Pharmingen       原厂货号：558095
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including
interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK
family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the
nucleus to promote transcription of cytokine-inducible genes. Seven Stat proteins have been cloned, each of which is differentially expressed
and/or activated in a cytokine-specific and cell type-specific manner. Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated
Gene Factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface
receptor. Stat2 is a 113-kDa protein having approximately 40% homology with Stat1a. Stat2 interacts with Stat1 for the efficient activation
of Stat1 in response to IFN-a, which is essential for normal transcriptional activity of the ISGF3 complex. Stat2 phosphorylation at the
tyrosine 690 residue (Y690) after IFN-a activation can occur independently of Stat1, but the localization and nuclear stability of
phosphorylated Stat2 is dependent on Stat1.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.