Hu CD335 (NKp46) APC 9E2/NKp46 100Tst

产品编号：BD-558051 品牌：BD-Pharmingen 原厂货号：558051
产品分类：抗体 > 一抗 > 染料标记抗体
应用分类：

包装：

100Tst

运保温度:

Store undiluted at 4°C

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描述：

The 9E2/Nkp46 monoclonal antibody specifically binds to CD335. CD335 is also known as the Natural killer cell p46-related protein

(NKp46) and the Natural cytotoxicity triggering receptor 1 (NCR1). CD335 is a 46 kDa type I membrane glycoprotein that is expressed on

resting and activated NK cells. Its extracellular region contains two C2-type, Ig-like domains. The transmembrane domain contains a

positively charged amino acid (Arg) which could be involved in stabilizing the association with CD3ζ. Its intracellular region does not contain

immunoreceptor tyrosine-based activating motifs (ITAM), but it is linked to intracytoplasmic transduction machinery by its association with

CD3ζ and FcεRIγ adaptor proteins. CD335 along with NKp30 and NKp44 are referred to as natural cytotoxicity receptors (NCR). These

receptors play very important roles in cells that kill virus-infected target cells, tumor cells and MHC-class I-unprotected cells.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.This APC-conjugated reagent can be used in any flow cytometer equipped with a dye, HeNe, or red diode laser

3.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .

4.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

5.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

6.The antibody was conjugated to APC under optimum conditions, and unconjugated antibody and free APC were removed.