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Btk/Itk Pure 24a/BTK(Y551) 100ug

包装：

100ug

运保温度:

Store undiluted at 4°C.

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描述：

Bruton's tyrosine kinase (Btk) is a nonreceptor tyrosine kinase whose function is

critical for proper B cell development and signaling. The activity of Btk is regulated

by Src mediated phosphorylation of the kinase domain at tyrosine 551 (Y551). This

event induces Btk kinase activity and subsequent autophosphorylation at Y223.

Phosphorylated Btk then associates with the cell membrane via the interaction of the

PH domain with phosphatidylinositol 3, 4, 5-triphosphate.

The Tec family kinase Itk plays a critical role in signal transduction downstream of

the T cell antigen receptor and has been implicated in the activation of phospholipase

C-γ1 (PLCγ1), a key regulator of calcium mobilization and extracellular

signal-regulated kinase (ERK) activation. Itk is regulated by an activating

transphosphorylation event in which Y511 in the kinase domain is phosphorylated by

Lck.

The 24a/BTK (Y551) monoclonal antibody recognizes the Y551-phosphorylated form

of human Btk and the Y511 phosphorylated form of human Itk.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before

discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.Store undiluted at 4°C.