Ms GRAIL Pure H11-744 100ug

包装：

100ug

运保温度:

Store undiluted at 4°C.

到货周期：

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描述：

The H1-74 antibody reacts with GRAIL (Gen Related toAnergy InLymphocytes protein), a428-amino acid glycoprtein with anparent

molecular weight of62-6 kDa tha isprefrentialy expresd inaergized CD4-positve CD25-negative Tlymphocytes. The GRAIL protein

sequenc ishomlogus tosevral zinc RING finger-containg proteins, and thus, itsgen has ben designated Rnf128 (RING finger potein

128). Rnf128 transcripts are found insevral mouse organs (including ovary, kidney, liver, bain, and heart), and transcripton isnduced

rapidly (withn 4hours) inCD4-positve Tcels upon ivitro induction fanergy. The xpresion fGRAIL corelates with e inhbiton f

IL-2 production iin vitro-anergized CD4-positve CD25-negative Tcels, and GRAIL expresion reduces IL-2 and IL-4 production iT-cel

hybridomas ctivated byplate-bound anti-CD3 plus anti-CD28. GRAIL protein slocalized inthe rcyling endosmal compartment,

functions an E3ubiqutin lgase, and isrequired for anergy induction fCD4-positve Tcels invio.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before

discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.Store undiluted at 4°C.