Ms CD1d/Ig Recom DimerX Pure 250ug

• 产品编号：BD-557599      品牌：BD-Pharmingen       原厂货号：557599
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

The CD1d:Ig fusion protein consists of the extracellular major histocompatibility complex (MHC) class I-like domains of the mouse CD1d
molecule fused with the VH regions of mouse IgG1 (see figure). Like MHC class I molecules, the CD1d noncovalently associates with β2
Microglobulin (β2M). For this reason, BD Pharmingen DimerX consists of recombinant CD1d:Ig and β2M. Recombinant CD1d molecules,
like the DimerX fusion protein, are useful for studying Natural Killer T (NKT)-cell function by immunofluorescent staining and flow
cytometric analysis of antigen-specific NKT cells.
The mouse CD1D1 gene encodes a non-polymorphic cell-surface protein that plays a role in antigen presentation to CD1d-restricted NKT
cells. Like the MHC class I molecules, CD1d associates noncovalently with β2M and is capable of binding and presenting lipid antigens.
While the natural ligand for CD1d is presently unknown, it is well documented that CD1d can bind and present the glycolipid, α-galactosyl
ceramide (α-GalCer*), a glycosphingolipid from the marine sponge. Glycosylphosphatidylinositol (GPI) has also been identified as a major
CD1d-associated component. Antigenic glycolipids such as α-GalCer associated with the CD1d molecule are presented and specifically
recognized by NKT cells expressing a highly conserved TCR, Vα 14Ja281, paired with diverse β chains such as Vβ 8.2 and Vβ 7. Mouse
CD1d:Ig shows differential staining intensities on Vα 14Ja281+ cells, based on the Vβ chain present, with Vβ 8.2+ cells predominantly
showing higher intensities than Vβ 7+ cells. The function and lineage marker expression of NKT cells and their interaction with CD1d has
been recently reviewed.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.