Hu CD271 PE C40-1457 100Tst

The C40-1457 monoclonal antibody specifically reacts with CD271, the nerve growth factor receptor (NGFR). CD271 is a transmembrane 75 

kDa protein that has been found localized to neuronal axons, Schwann cells, and perineural cells of peripheral nerves. It is also expressed by 

cells in some epithelial, mesenchymal and lymphoid tissues. NGFR is the receptor for nerve growth factor (NGF), a polypeptide that is 

essential for normal development of the nervous system. NGF promotes survival and differentiation of sympathetic and sensory neurons 

during embryological development of peripheral neurons. NGF binds to two distinctive surface receptors expressed by target cells, the 

p140-TrkA (NTRK1) and the p75 NGFR. High affinity binding of NGF requires that both receptor molecules be expressed. NGFR has been 

found on human and rat lymphocytes. A subset of lymphoid cells in the spleen, lymph nodes, and follicular dentritic cells in germinal centers 

of reactive lymph nodes were found to express CD271. It has been reported that NGFR interaction with its ligand, NGF, may play a role in 

immunoregulation. NGF may function as a B-cell growth factor. 

 

1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 X 10e6 cells in a 100-μl experimental sample (a test).

2.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

3.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

4.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

5.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.