MGMT Pure MT5.1 100ug

产品编号：BD-557045 品牌：BD-Pharmingen 原厂货号：557045
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

100ug

运保温度:

Store undiluted at 4°C.

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描述：

The repair of mismatched DNA is essential to maintaining the integrity of genetic information over time. The important role played by DNA
repair enzymes is emphasized by the fact that they are highly conserved from bacteria to yeast to mammals. In bacteria, DNA repair involves
the activity of repair enzymes including the MutL, MutH, and MutS proteins, as well as an enzyme originally identified in bacteria, and
subsequently in all mammalian species, MGMT (methylguanine-DNA methyltransferase). Human MGMT is a 21 kDa protein which protects
cells from the mutagenic effect of alkylating agents, which add a methyl group to the O6 position of guanine in DNA, producing
O6-methylguanine. While MGMT is generally ubiquitously expressed in mammalian cells, the expression levels within cell and tissue types
can be quite variable. Certain tumor cell types have been identified which express neither MGMT protein or mRNA, despite the apparent
normal expression of the MGMT gene. The variable expression of MGMT may be a factor in the susceptibility of cells and tissues to the
mutagenic effects of alkylating agents. It has been suggested that methylation of cytosine in the MGMT gene and promoter region may
correlate with the expression of the MGMT gene product.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.