Hu Bik Pure C33-1 100ug

• 产品编号：BD-557040      品牌：BD-Pharmingen       原厂货号：557040
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Members of the Bcl-2 (B-cell lymphoma-2) family play a major role in regulating the response of cells to apoptotic signals. Several of these
proteins function as inhibitors of cell death (e.g., Bcl-2 and Bcl-XL), while others promote cell death (e.g., Bcl-XS, Bax and Bad). Members
of this family contain conserved domains, designated BH1, BH2 and BH3, which facilitate protein-protein interactions. Differential
interaction among Bcl-2 proteins, as well as their interaction with other cellular or viral proteins, can regulate whether a cell undergoes, or is
protected from, an apoptotic death. For example, Bcl-2 normally blocks cell death by forming heterodimers with the pro-apoptotic proteins
Bax and Bak. Bcl-2 Interacting Killer (Bik, also known as Nbk) is a novel human protein which is functionally homologous to pro-apoptotic
members of the Bcl-2 family. Bik contains the BH3 conserved domain common to Bcl-2 proteins, but lacks either BH1 or BH2 conserved
domains. Bik has been reported to interact with and antagonize the activity of anti-apoptotic proteins including Bcl-2, Bcl-X4 as well as the
viral proteins Epstein Barr BHRF1 and adenovirus E1B-19K. Blk, a mouse protein which is structurally and functionally homologous to
human Bik, has also been identified. In the mouse system, Blk appears to induce apoptosis by activation of caspase-9.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.