MASH1 Pure 24B72D11.1 100ug

包装：

100ug

运保温度:

Store undiluted at 4°C.

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描述：

MASH1 and MASH2 (Mammalian achaete-schute Homolog 1 and 2) are basic helixloop-helix transcription factors which are mammalian

homologs of the achaete-schute gene family that is required for neuronal development in Drosophila. The bHLH motif is present in many

types of transcription factors including E2-2, E47, MyoD and others. MASH1 has been shown to heterodimerize with other bHLH containing

transcription factors. MASH1-E12 heteromers bind to and promote transcriptional activation of muscle creatine kinase, a known target for

MyoD activation. However, MASH1 appears to play its primary role during early development of the autonomic nervous system. In

committed neuronal precursor cells, early expression of MASH1 activates a subset of neuron-specific genes to promote differentiation. Thus

null mutations in the MASH1 gene suggest that MASH1 is a valuable marker for investigation of neural development in mammals. MASH1 is

observed as an ~34 kDa protein by SDS-PAGE

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before

discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.Store undiluted at 4°C.