Hu Caspase-7 Pure B94-1 100ug

• 产品编号：BD-556541      品牌：BD-Pharmingen       原厂货号：556541
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Caspase-7 is a member of a family of cysteine proteases which play a critical role in the induction of apoptosis. Caspase-7 is structurally and
functionally most similar to caspase-3. These proteases are expressed as proenzymes which are processed into large and small subunits that
associate to form the active enzyme. Caspase-7 may also exist as alternative splice forms, i.e., Mch3α and Mch3β. A novel interaction
between Mch3α and the 17 kDa subunit of caspase-3 has been demonstrated in vitro, producing a heteromeric enzyme which is proteolytically
active. Active caspase-7 can move to the mitochondrial fraction of cells undergoing Fas-mediated apoptosis, whereas active caspase-3 is
primarily cytosolic. Caspase-7 is activated by caspase-31 and by granzyme B. Active caspase-7 can cleave the nuclear substrate PARP1 as
well as the sterol regulatory element-binding protein 1 (SREBP-1). Caspase-7 migrates at a molecular weight of 35 kDa in SDS/PAGE.
Clone B94-1 recognizes the 35 kDa and 17 kDa form human caspase-7. The specificity of the antibody was verified by immunoprecipitation
and western blot analysis of active, recombinant human caspase-7 and of endogenous caspase-7 in cell lysates. A synthetic peptide
corresponding to amino acids 25-42 of human caspase-7 was used as immunogen.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.