Hu IKKAlp Pure B78-1 100ug

• 产品编号：BD-556532      品牌：BD-Pharmingen       原厂货号：556532
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

The nuclear transcription factor kappa-B, NF-κB, is controlled by interaction with an inhibitory subunit, I-κB, which restricts NF-κB to the
cytoplasm. Following stimulation by various cytokines or other stimuli, I-κB becomes degraded and NF-κB is released to the nucleus. The
release of I-κB from NF-κB is thought to be a critical point in the activation of NF-κB signal pathways. A group of proteins form an NF-κB
regulatory complex, or signalsome. Two members of this complex are a pair of closely related kinases, IKKα and IKKβ (also called IKK-1 and
IKK-2). IKKα and IKKβ are serine/threonine kinases which share approximately 50% sequence identity. In addition to their kinase domains,
these proteins each contain leucine zipper and helix-loop-helix regions which facilitate their interaction with each other as well as
interaction(s) with other proteins within the IKK complex. Both IKKα and IKKβ phosphorylate critical residues of I-κB, thus targeting it for
subsequent degradation. IKKα and IKKβ become activated themselves following phosphorylation by upstream kinases, including
NF-κB-inducing kinase (NIK) and MEKK1. Thus the IKK kinases play an important role in the activation of NF-κB. IKKα migrates at a
molecular weight of 85 kD in SDS-PAGE. Clone B78-1 recognizes human IKKα. It does not cross-react with IKKβ. Full length, recombinant
human IKKα was used as immunogen. The reactivity of B78-1 was verified by immunoprecipitation and western blot analysis.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.