Ms Id3 Pure B72-1 100ug

产品编号：BD-556524 品牌：BD-Pharmingen 原厂货号：556524
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

100ug

运保温度:

Store undiluted at 4°C.

到货周期：

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描述：

Id proteins were originally characterized as inhibitors of DNA binding and cell differentiation. Id1 through 4 contain an evolutionarily
conserved helix-loop-helix (HLH) sequence which is critical for protein-protein interaction(s). Most HLH transcription factors contain a basic
amino acid region adjacent to the HLH sequence, the bHLH sequence, which is responsible for DNA binding. bHLH transcription factors fall
into 2 major groups designated class A factors, e.g.,E2.2 and E47, and class B factors, e.g., MyoD and myogenin. In vitro studies demonstrate
distinct interaction(s) between Id proteins and bHLH transcription factors. While Id proteins contain an HLH domain, they lack the basic
region which is required for DNA binding. Therefore, Id proteins are negative regulators of transcription since complexes which contain them
do not bind DNA. Id proteins are variably expressed throughout the cell cycle and are regulated by phosphorylation by cyclin-cdk complexes.
Thus, Id proteins play an important role in transcriptional regulation of cell cycle related genes. Overexpression of Id3 can induce apoptosis in
serum-starved fibroblasts by a mechanism which is correlated to Id3-mediated cell cycle progression and is rescued by over expression of the
antiapoptotic proteins Bcl-2 and Bcl-XL. Clone B72-1 recognizes mouse Id3. It does not cross react with mouse Id1 or mouse Id2. A fusion
protein containing full length mouse Id3 was used as immunogen. The antibody is routinely tested by western blotting of the Id3-fusion
protein. The Id3-fusion protein is observed at 43 kDa (fusion protein MW ~28 kDa and Id3 MW is ~13 kDa).

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.