PRK Pure B37-2 100ug

• 产品编号：BD-556518      品牌：BD-Pharmingen       原厂货号：556518
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

PRK (proliferation-related kinase) is a serine/threonine kinase with significant homology to members of the polo family of protein kinases
(e.g., mouse fnk/snk, human and mouse plk). There are two domains in the polo family kinases, an amino-terminal kinase domain and a
carboxylterminal regulatory domain. Polo kinases have been previously implicated in cell division. Tissue specific expression of PRK mRNA
is normally fairly restricted, but includes human placenta, and to a lesser degree, ovaries and peripheral blood leukocytes. PRK mRNA is
generally undetectable in many cell lines but may be induced in some cell types by mitogens or following addition of serum to previously
serum-deprived cells. PRK expression is tightly regulated at various levels during different stages of the cell cycle. For example, PRK kinase
activity in lung fibroblasts is relatively low during mitosis, G1, and G1/S; PRK activity peaks in late S and G2. Recombinant human PRK is
capable of phosphorylating Cdc25C, a positive regulator for the G2/M transition. Thus, PRK appears to play an important role in regulating
the onset and/or progression of mitosis in mammalian cells. PRK was originally reported to migrate at 68 kD in SDS-PAGE. We observe that
PRK migrates at ~72 kD. A recombinant protein corresponding to amino acids 334 to 607 of human PRK was used as immunogen.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.