Hu Caspase-9 Pure B40 100ug

• 产品编号：BD-556510      品牌：BD-Pharmingen       原厂货号：556510
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Caspase 9 (ICE-LAP6, Mch-6, Apaf-3) is a member of a family of cysteine proteases which play a critical role in the induction of programmed
cell death. Members of this family have been grouped according to sequence homology as being either ICE-like proteases (caspases 1, 4 and
5) or Ced-3- like proteases (caspases 3, 6, 7, 9 and 10a). Caspase-9 is produced as a 48 kD precursor (procaspase-9) which contains an
N-terminal prodomain with high homology to caspase-2. Procaspase-9 may be processed into subunits which heterodimerize to form the
active enzyme. Activation of caspase-9 occurs in the presence of cytochrome c (Apaf-2), following an interaction between caspase-9 and
Apaf-1. Activation may also be triggered directly by the cytotoxic T-cell protease, granzyme B. Active caspase-9 cleaves and thus activates
caspase-3 and is also a relevant target of active caspase-3. Caspase- 9 can also cleave the nuclear protein PARP. Northern blot analysis
suggests that high expression of caspase-9 is found in the heart, testis and ovary.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.