Hu D4-GDI Serum Poly 1067 0.1mL

产品编号：BD-556498 品牌：BD-Pharmingen 原厂货号：556498
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

运保温度:

Store undiluted at 4°C.

到货周期：

登录后查看

标准价：

￥客户可见

会员价：

￥客户可见

积分：

客户可见分

登录之后可加入购物车购买，请您

运费与支付说明：

1.含干冰类产品有运费；

2. 必须现金付款或有信用额度的会员才可以直接发货，否则需要等待现金付款信息。

描述：

Guanine nucleotide dissociation inhibitors (GDIs) are negative regulators of Rho GTPases, a family of GTP-binding proteins which are
thought to control the cytoskeletal and membrane changes that accompany cell death. D4-GDI and Rho-GDI are related GDI proteins, which
differ in their cell-specific expression as well as in their ability to regulate GTPases. Rho-GDI is ubiquitously expressed and is a potent
regulator of GTPases. By comparison, D4-GDI expression appears to be restricted to D4-GDI hematopoietic cells, and its regulatory activity
appears to be lower than Rho-GDI. D4-GDI has been shown to be a substrate for the apoptotic associated proteases caspase-1 (ICE) and
caspase-3 (CPP32). Active caspase-1 and caspase-3 cleave the 28 kD intact form of D4-GDI to 18 kD and 23 kD truncated forms,
respectively. This process is believed to have significance with respect to the regulation of Rho GTPases during apoptosis. When used
appropriately, the polyclonal rabbit anti-human D4-GDI antibody (Cat. No. 556498) recognizes the 28 kD intact form of human D4-GDI, but
not the 18 and 23 kD cleaved fragments.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.