Rat mGluR1Alp Pure G209-2048 100ug

包装：

100ug

运保温度:

Store undiluted at 4°C.

到货周期：

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描述：

Glutamate is a major excitatory neurotransmitter in mammalian brain. Glutamatergic neurotransmission is mediated by a family of glutamate

receptors that can be grouped into two classes, ionotropic (GluR) and metabotropic (mGluR) receptors. The metabotropic glutamate receptors

consist of at least seven subtypes that can be divided into three groups on the basis of their sequence similarities, intracellular second

messengers and agonist selectivities. These groups are: 1) mGluR1 and mGluR5; 2) mGluR2 and mGluR3; and 3) mGluR4, mGluR6 and

mGluR7. mGluR1 and mGluR5 are coupled to the inositol phosphate/Ca[2+] signal transduction pathway, whereas the other five receptors are

linked to the inhibition of the cAMP cascade. mRNA analysis shows that the seven receptors have different expression patterns in the central

nervous system. For example, the highest level of mGluR1 mRNA expression is found in the cerebellar Purkinje cells. mGluR7 mRNA is

moderately expressed in these cells, whereas the mRNA of the other five mGluRs is barely detectable. Three splice variants have been

described for mGluR1: mGluR1α (145 kDa), mGluR1β (97 kDa), and mGluR1c (97 kDa).

Clone G209-2048 recognizes rat mGluR1α. It does not cross-react with the other splice mGluR1 variants, mGluR1β, and mGluR1c.

Additionally, G209-2048 does not cross-react with mGluR5, the most closely related mGluR family member. A full length recombinant rat

mGluR1 fusion protein was used as immunogen.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before

discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.Store undiluted at 4°C.