Hu Bak Pure G317-2 100ug

包装：

100ug

运保温度:

Store undiluted at 4°C.

到货周期：

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描述：

Bak (for Bcl-2 homologous Antagonist/Killer) is a recently identified member of the Bcl-2 family. Bcl-2 family members are involved in

mediating programmed cell death or apoptosis, and share two highly conserved functional regions, Bcl-2 homology 1 and 2 (BH1 and BH2).

Several of the family members, including Bcl-2, act as inhibitors of apoptosis, whereas others such as Bax promote cell death. Like Bax

promote cell death. Like Bax, Bak primarily promotes apoptosis. However, unlike Bax, Bak has also been shown to inhibit cell death. Bak

inhibited both serum-starvation and drug induced apoptosis when overexpressed in an Epstein-Barr virus (EBV)-transformed cell line.

However, Bax did not inhibit cell death under the same conditions. Bak mNRA has been identified in a wide variety of fetal and adult tissues,

with the highest levels observed in heart and skeletal muscle. The apparently ubiquitous expression of Bak has lead to the suggestion that its

function may be mediated by cell death inhibitory factors, particularly in cell types with a long life span. Bak migrates at a reduced molecular

weight ~24 kDa. G317-2 reacts with human Bak. A synthetic peptide corresponding to the first 50 amino acids of human Bak was used as

immunogen.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before

discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.Store undiluted at 4°C.