描述：
Members of the Bcl-2 family play a major role in regulating the response of cells to a wide variety of apoptotic signals. The first member of
this multifamily, Bcl-2, was discovered in the mid 1980s through its involvement in t(14;18) chromosomal translocations commonly found in
a subset of follicular B-cell lymphomas. Bcl-2 blocks apoptosis, and translocation of Bcl-2 sequences from chromosome 18 onto the
transcriptionally active immunoglobulin locus at chromosome band 14q32 in B cells deregulates Bcl-2 gene expression, resulting in high
levels of Bcl-2 mRNA and protein expression. Deregulation of the Bcl-2 gene, by translocations or other mechanisms, appears to contribute to
tumorigenesis by prolonging cell survival rather than by accelerating the rate of cell proliferation. A variety of Bcl-2 homologues have since
been described in humans and other mammals, leading to the definition of a multigene family. Like Bcl-2, some Bcl-2 family members block
apoptosis, whereas others promote apoptosis and inhibit Bcl-2 activity. Bcl-X is a Bcl-2 homologue that has two isoforms, resulting from
alternative splicing. Bcl-X-L (long) is a 241 amino acid protein that is 47% homologous to Bcl-2 on the amino acid level. Bcl-X-S (short) is a
178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the Bcl-2 protein family. bcl-X-L blocks
cell death, whereas Bcl-X-S inhibits Bcl-2 and promotes cell death. The antibodies recognize both mouse and human Bcl-X-L (long) and
Bcl-X-S (short) proteins. A synthetic peptide corresponding to amino acids 46-66 of human Bcl-X was used as immunogen. This region
corresponds to a unique domain that lacks homolog with other known members of the Bcl-2 family.
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.
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