Hu MsH2 Pure G219-1129 100ug

包装：

100ug

运保温度:

Store undiluted at 4°C.

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描述：

The repair of mismatched DNA is essential to maintaining the integrity of genetic information over time. In bacteria the DNA repair process is

accomplished by the MutL, MutH, and MutS proteins. The MutS protein initially recognizes and binds to mismatched DNA. Following this,

MutH, an endonuclease, and MutL form a complex with MutS and carry out an excision repair mechanism. When bacteria are deficient in one

of these enzymes a mutator phenotype arises characterized by genetic instability. The important role played by DNA repair enzymes is

emphasized by the fact that they are highly conserved from bacteria to yeast to mammals. In yeast the proteins are called MutS homolog 2

(MSH2), MutL homolog (MLH1), and PMS1 which is also a homolog of MutL. MSH2 is involved in the initial recognition of mismatched

nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a

heterodimer of MLH1 and PMS1 which together help facilitate the later steps in mismatch repair. The human homologs of DNA mismatch

repair enzymes MLH1, PMS2, and MSH2 have recently been cloned. G219-1129 recognizes human MSH-2. A recombinant full-length

human MSH2 protein was used as immunogen.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before

discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.Store undiluted at 4°C.