Hu Cdk7 Pure MO-1 100ug

包装：

运保温度:

Store undiluted at 4°C.

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描述：

Cyclins and cyclin-dependent kinases (Cdks) are subunits of cell cycle dependent protein kinases that regulate key events during the cell cycle.

For orderly progression to take place, Cdks must become fully active only at appropriate times in the cell cycle, and only in appropriate

subcellular locations. For example, Cdk2 is activated during the S and G2 phases of the cell cycle and is associated with cyclins A and E. The

monomeric form of Cdk2 is inactive as a kinase, its conformation has multiple steric impediments to catalysis. Activation occurs in two steps,

and is accompanied by conformational changes that remove the steric hindrances. The first step is the binding of a single Cdk2 monomer to a

single molecule of cyclin. This allows for some enzymatic activity, but full activation of Cdk2 and all other known Cdks requires

phosphorylation of a conserved threonine residue. Cak (for Cdk-activating kinase) has been shown to phosphorylate the threonine residue and

activate Cdk2/cyclin complexes. Cak is itself a cyclin/Cdk complex consisting of cyclin H and Cdk7. Cyclin H is the regulatory subunit of the

Cak enzyme, whereas Cdk7 is the catalytic subunit. Thus, Cak functions as a regulator of other cyclin/kinase complexes, suggesting that

cyclin/kinase cascades may exist. Cdk7 migrates as a single band at a reduced molecular weight of 36-42 kDa. The MO-1 antibody recognizes

human Cdk7.5 Recombinant human Cdk7 was used as an immunogen.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before

discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.Store undiluted at 4°C.