Ms Rat CD56 Pure N-CAM 13 100ug

包装：

运保温度:

Store undiluted at 4°C.

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描述：

Cell adhesion molecules are present of the surface of most cells (CAMs). Neural CAMs play a key role in the development of the embryonic

nervous system. Expression of neural CAMs provides neurons with a means of attaching to and interacting with other cells and the

extracellular matrix. The cell surface adhesion molecule N-CAM is important in mediating initial axon outgrowth and cell migration during

development. In the mature nervous system, N-CAM is important in regulating cell interactions. Additionally, the expression of several

CAMs, including N-CAM, is altered following injury to the peripheral nervous system. Alternative splicing of N-CAM mRNA results in

several N-CAM isoforms. The three major isoforms are referred to as 180 kDa, 140 kDa, and 120 kDa. The functional significance of the

different isoforms of N-CAM remains to be to be fully elucidated. Individual isoforms undergo various post-translational modifications,

including the addition of polysialylic acid residues to embryonic forms. The highly polysialylated forms of N-CAM present in embryos and

neonates are lost during maturation and replaced by less polysialylic acid-laden mature forms of N-CAM. BD Biosciences Pharmingen offers

N-CAM antibodies recognizing the major isoforms of adult and embryonic NCAM (Clone N-CAM 13, Cat. No. 556324), a subset of adult

and embryonic N-CAM (clone 12F11, Cat. No. 556323), and exclusively embryonic N-CAM (clone 12F8, Cat. No. 556325). The antibody

recognizes the three major isoforms of mouse and rat N-CAM (120 kDa, 140 kDa, and 180 kDa); it does not cross-react with chicken N-CAM.

The antibody reacts with an extracellular epitope of N-CAM. Mouse membrane fractions were used as immunogen.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before

discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.Store undiluted at 4°C.