描述：
Microtubule-associated protein 2 (MAP2) is a neuronal cytoskeletal protein that binds to tubulin and stabilizes microtubules. It is expressed in
the cell body and dendrites of neurons, but is absent in neuronal processes. The expression of MAP2 is developmentally regulated, and there
are multiple high and low molecular weight isoforms, all derived from one MAP2 gene. MAP2a, MAP2b, and MAP2c are the three major
MAP2 isoforms. The high molecular weight MAP2 isoforms, MAP2a and MAP2b consist of a large projection arm and a short microtubule
binding domain. The low molecular weight MAP-2 isoform, MAP2c, lacks most of the projection arm of the high molecular weight isoforms.
MAP2c is the earliest expressed MAP2 and is derived by alternative splicing MAP2a and MAP2b are considered to be adult expressed MAPs,
with MAP2a expression occuring later in development than MAP2b expression. MAP2a is thought to result from a post-translational
modification of MAP2b. High molecular weight MAP2 isoforms (2a and 2b) migrate as a doublet at a molecular weight of >300 kDa. The low
molecular weight MAP2 isoform 2c migrates at 70 kDa.
The Ap-20 antibody recognizes high molecular weight MAP2 isoforms MAP2a and MAP2b. Specifically, it has been shown to recognize
MAP2a and MAP2b from human, bovine, rat, frog, and quail cells and tissues. Ap-20 does not recognize the low molecular weight MAP2
isoforms (MAP2c) or other microtubule proteins. Ap-20 reacts with an epitope between amino acids 997-1332 of high molecular weight
MAP2 isoforms.4 Bovine MAP2 was used as immunogen.
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
