The B6H12 monoclonal antibody specifically binds to a 42-52 kDa N-linked glycan protein. CD47 antigen, also known as integrin-associated
protein (IAP), is expressed on all hematopoietic cells, including leukocytes, platelets and erythrocytes. It is also expressed on epithelial cells,
endothelial cells, fibroblasts and many tumor cell lines. CD47 may play a role as a signal transducer in the regulation of cation fluxes across
cell membranes and in the chemotactic and adhesive interactions of leukocytes with endothelial cells. The B6H12 antibody is capable of
blocking phagocytosis of microparticles by peripheral blood granulocytes. It has also been reported to induce proliferation of CD3-activated T
cells.
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注意事项:
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.