The monoclonal antibody 10.1 reacts with CD64, a 75 kD type I transmembrane glycoprotein that is a high affinity receptor for IgG (FcγRI).
CD64, a key receptor in the development of immune responses, has a dual role as a low affinity receptor for IgG3 and high affinity receptor for
IgG2a linking innate and adaptive immunities. CD64 mediates endocytosis, phagocytosis, antibody-dependent cellular toxicity, cytokine
release and superoxide generation. CD64 is expressed largely on macrophages and dendritic cells.
原厂资料:
注意事项:
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.