Ms CD152 NALE 9H10 500ug

包装：

运保温度:

Store undiluted at 4°C.

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描述：

The 9H10 antibody reacts with CD152 (CTLA-4), which is expressed on activated T lymphocytes 2-3 days after stimulation through T cell

receptor. CTLA-4 has significant similarity to CD28 in amino acid sequence, structure, and genomic organization. Furthermore, CD152 and

CD28 share common B7 family counter-receptors. Unlike CD28, CD152 expression at both mRNA and protein level appears to be restricted

to activated T cells with a maximal surface expression between 48 and 72 hours post-activation. The regulation of CTLA-4 protein expression

is complex and can involve changes in the rate of transit between intracellular stores and the cell surface. Whereas CD28 delivers a

co-stimulatory signal required for T-cell activation, CTLA-4 is a negative regulator of cell-mediated immune responses. CD152 may play roles

in induction and/or maintenance of immunological tolerance, regulation of protective immunity, and regulation of some aspects of thymocyte

maturation. This hamster mAb to a mouse leukocyte antigen does not cross-react with rat leukocytes.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before

discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.Store undiluted at 4°C.