Rat CD8b Pure 341 500ug

产品编号：BD-554971 品牌：BD-Pharmingen 原厂货号：554971
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

500ug

运保温度:

Store undiluted at 4°C.

到货周期：

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描述：

The 341 antibody reacts with the β chain of the CD8 antigen on most thymocytes and a subpopulation of mature T lymphocytes (ie, MHC
class I-restricted T cells, including most T suppressor/cytotoxic cells). The CD8 α and β chains (CD8a and CD8b, respectively) form a
heterodimer on the surface of most thymocytes and thymus-dependent T suppressor/cytotoxic cells, whereas intestinal intraepithelial
lymphocytes, many CD8+ T cells of athymic rats, many activated CD4+ T cells, and most NK cells express CD8a without CD8b. It has been
suggested that the expression of the CD8a/CD8b heterodimer is restricted to thymus-derived T lymphocytes. CD8 is an antigen co-receptor on
the T cell surface which interacts with MHC class I molecules on antigen-presenting cells. It participates in T-cell activation through its
association with the T-cell receptor complex and protein tyrosine kinase lck. Macrophages have also been reported to express CD8 α and β
chains, which are involved in signal transduction. The 341 mAb blocks proliferative and cytotoxic in vitro responses of CD8+ effectors to
allogeneic cells.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.