Hu CD123 NALE 7G3 500ug

产品编号：BD-554526 品牌：BD-Pharmingen 原厂货号：554526
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

500ug

运保温度:

Store undiluted at 4°C.

到货周期：

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描述：

The 7G3 monoclonal antibody specifically reacts with human CD123, the 70 kD IL-3 receptor α chain (IL-3Rα), which associates with the
120-140 kD β subunit. The β chain is shared with the receptors for interleukins IL-5 and GM-CSF. IL-3Rα is expressed on hematopoietic
progenitors and plays an important role in hematopoietic progenitor cell growth and differentiation. It is also expressed by mast cells,
macrophages and a CD5+ B cell subset. This antibody has been reported to block the binding of 125I-IL-3 to high and low affinity IL-3
receptors. In functional experiments, this antibody was found to inhibit acute myeloid leukemia cell proliferation, basophil histamine release,
endothelial cell-mediated IL-8 secretion, and neutrophil transmigration. This antibody has been reported to be useful for immunoprecipitation,
Western blot and immunofluorescent staining for flow cytometry. At the Fifth HLDA Workshop, the human IL-3 receptor was designated
CD123.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.