Hu c-erbB-2 Pure 3B5 100ug

• 产品编号：BD-554299      品牌：BD-Pharmingen       原厂货号：554299
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

C-erbB-2 (also known as HER2/neu), a 185 kDa transmembrane glycoprotein, is a member of the type 1 growth factor receptor subfamily
which also includes c-erbB-3, c-erbB-4 and the epidermal growth factor receptor (EGFR), also known as c-erbB-1. Members of this receptor
subfamily mediate the proliferation and differentiation of normal cells. They have a common structure consisting of an extracellular domain, a
transmembrane region, and a cytoplasmic sequence. The extracellular regions contain two cysteine-rich domains, and the intracellular regions
have sequence homology to known tyrosine kinases. C-erbB-2 reactivity has been detected in proximal kidney tubules, mucosal epithelium in
the gastrointestinal tract, and squamous epithelium in skin. Most normal adult tissues show little or no reactivity with antibodies against
c-erbB-2. However, c-erbB-2 is overexpressed in many human breast, stomach, ovary and bladder carcinomas. EGFR, c-erbB-3 and c-erbB-4
are also overexpressed in various human tumor cells, and it is thought that aberrant activation of type 1 growth factor kinase activities may
contribute to tumor progression.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.