Hu Androgen Rcptr Pure G122-77 100ug

• 产品编号：BD-554226      品牌：BD-Pharmingen       原厂货号：554226
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

The androgen receptor (AR) mediating androgen effects is a member of the steroid and thyroid hormone receptor gene superfamily encoding
ligand dependent nuclear transcription factors. They can be divided into three main domains: an N-terminal domain which modulates
transcription efficiency, a central DNA domain which binds to a target gene hormone response element and a C-terminal hormone binding
domain. Androgens are necessary for normal male development and function. They exert their effects on target tissue through binding to the
AR, followed by association of the AR complex with specific binding sites on DNA. This AR complex may induce or repress gene
transcription. Mutations in the AR gene are associated with androgen insensitivity syndrome, a disorder that causes XY genotypic males to
develop as phenotypic females because of their inability to respond to androgens. AR mutations have also been identified in human prostate
cancer specimens and the LNCaP human prostate cancer cell line (ATCC CRL-1740). Monoclonal and polyclonal antibodies to the AR have
identified AR-positive cells in a variety of tissues including male and female sexual organs, kidney, liver, adrenal cortex, pituitary gland,
skeletal, cardiac and smooth muscle cells. The androgen receptor has been reported to migrate at a molecular weight of 100 kDa by
SDS-PAGE. G122-77 has been reported to recognize the N-terminal portion of the human androgen receptor protein and reportedly does not
recognize estrogen or progesterone receptors.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.